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Rare blood types

What’s the rarest blood type?

AB negative is the rarest blood type - just 1% of our donors have it.

The eight main blood types are made up of a combination of:

  • the ABO blood group, which gives the letter part, and
  • the Rhesus group (Rh), which gives the positive or negative part
The Rhesus group gives the positive or negative part of your blood type

Of our donors:

  • 3% belong to group AB
  • 10% belong to group B
  • 38% belong to group A
  • 48% belong to group O

It’s much more common to have Rh positive blood than Rh negative blood:

  • 23% of donors have Rh negative blood
  • 77% of our donors have Rh positive blood

So having both AB and Rh negative blood is rare. But it’s not quite as simple as that.

Rare subtypes

Although the ABO and Rh groups are the most important for blood transfusions, there are more than 30 other known blood groups.

Each blood group has a combination of sugars and proteins called antigens that are found on the outside of red blood cells.

There are more than 600 antigens so there’s potential for a lot of variation between different people.

If your blood has rare antigens or lacks common antigens you could have a rare subtype.

Why are blood subtypes important?

Most blood transfusions are based on the ABO and Rh groups.

But if someone needs ongoing transfusions, blood works best when it closely matches their own.

If you have a rare subtype, your blood could be vital for a patient who also shares that subtype.

If you give blood, you'll find out if you have a rare subtype after your first donation.

Ethnicity and rare blood types

Your blood type is inherited from your parents in the same way as eye or hair colour.

This means you are more likely to share the same blood type or subtype as someone from the same ethnic background.

For example, Ro is a rare subtype - just 2% of donors have it - but it’s ten times more common in black people than white people.

Growing demand for the Ro subtype is one of the reasons why we need more black donors.

Where do donations of rare blood come from?

There are three ways we provide rare blood:

  1. Fresh blood cells from routine donations – this is our preferred option
  2. Contacting donors with the rare blood types and asking them to donate
  3. Using frozen rare blood – this is used as a last resort for the rarest blood types. Rare blood can be frozen for up to 30 years and thawed for transfusion when it's needed

Supplying rare blood across the world

As well as supplying rare blood to people in England, we can also help find rare blood for people in other countries.

We manage a list of rare blood donors from 27 countries and store frozen rare blood. When a request for rare blood comes in we search these databases for a match.


Become a blood donor


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More information about the different blood types that provide a lifeline to all kinds of patients